What is the main conflict of Othello?

The main conflict of Othello is Iago's manipulation and jealousy, which leads to the downfall of Othello and Desdemona. Iago, a cunning and envious ensign, is secretly resentful of Othello's promotion and marriage to Desdemona. He plots to destroy Othello's happiness by planting seeds of doubt and suspicion in Othello's mind, exploiting Othello's insecurities and vulnerabilities. Iago's machinations successfully drive Othello to a state of paranoia and irrationality, leading to the tragic deaths of Desdemona and Othello himself.