What does murther hath broke ope mean in macbeth?

The phrase "murther hath broke ope" in Macbeth means that murder has broken open or forced open the door to further evil and destruction. It suggests that once a person commits murder, it sets in motion a chain of events that leads to more violence and chaos. The phrase is used by Macbeth after he has killed King Duncan, and it reflects his growing sense of guilt and remorse for his actions. He realizes that he has crossed a moral boundary and that there is no going back. The phrase also foreshadows the eventual downfall of Macbeth and his wife, Lady Macbeth, as their guilt and paranoia consume them.