* Connie Britton as Vivien Harmon
* Dylan McDermott as Ben Harmon
* Evan Peters as Tate Langdon
* Taissa Farmiga as Violet Harmon
* Denis O'Hare as Larry Harvey
* Jessica Lange as Constance Langdon
* Zachary Quinto as Chad Warwick
* Sarah Paulson as Billie Dean Howard
* Kate Mara as Hayden McClaine
* Jamie Brewer as Adelaide Langdon
* Alexandra Breckenridge as Moira O'Hara
* Lizzie Brocheré as Grace Bertrand
* Joseph Fiennes as Dr. Charles Montgomery
Season 2 (Asylum)
* Zachary Quinto as Dr. Oliver Thredson
* Sarah Paulson as Lana Winters
* Lily Rabe as Sister Mary Eunice McKee
* Evan Peters as Kit Walker
* Jessica Lange as Sister Jude Martin
* James Cromwell as Dr. Arthur Arden
* Joseph Fiennes as Monsignor Timothy Howard
* Chloë Sevigny as Shelley
* Jenna Dewan-Tatum as Terry
* Mark Consuelos as Spivey
* Adam Levine as Leo Morrison
* Frances Conroy as Shachath
Season 3 (Coven)
* Kathy Bates as Madame Delphine LaLaurie
* Jessica Lange as Fiona Goode
* Taissa Farmiga as Zoe Benson
* Sarah Paulson as Cordelia Foxx
* Evan Peters as Kyle Spencer
* Lily Rabe as Misty Day
* Emma Roberts as Madison Montgomery
* Frances Conroy as Myrtle Snow
* Denis O'Hare as Spalding
* Gabourey Sidibe as Queenie
* Angela Bassett as Marie Laveau
* Leslie Jordan as Quentin Fleming
Season 4 (Freak Show)
* Jessica Lange as Elsa Mars
* Sarah Paulson as Bette and Dot Tattler
* Evan Peters as Jimmy Darling
* Denis O'Hare as Stanley
* Emma Roberts as Maggie Esmerelda
* Finn Wittrock as Dandy Mott
* Frances Conroy as Gloria Mott
* Michael Chiklis as Dell Toledo
* Kathy Bates as Ethel Darling
* Angela Bassett as Desiree Dupree
* Wes Bentley as Edward Mordrake
Season 5 (Hotel)
* Lady Gaga as Elizabeth Taylor
* Matt Bomer as Donovan
* Kathy Bates as Iris
* Sarah Paulson as Sally
* Evan Peters as Mr. March
* Chloe Sevigny as Alex
* Wes Bentley as John Lowe
* Denis O'Hare as Liz Taylor
* Angela Bassett as Ramona Royale
* Finn Wittrock as Tristan Duffy
* Cheyenne Jackson as Will Drake
* Max Greenfield as Gabriel
Season 6 (Roanoke)
* Kathy Bates as Agnes Mary Winstead
* Lily Rabe as Shelby Miller
* Sarah Paulson as Audrey Tindall
* Evan Peters as Rory Monahan
* Angela Bassett as Monet Tumusiime
* Cuba Gooding Jr. as Dominic Banks
* Adina Porter as Lee Harris
* Wes Bentley as Dylan
* Andre Holland as Matt Miller
* Cheyenne Jackson as Sidney Aaron James
* Lady Gaga as Scáthach
Season 7 (Cult)
* Sarah Paulson as Ally Mayfair-Richards
* Evan Peters as Kai Anderson
* Alison Pill as Ivy Mayfair-Richards
* Billy Eichner as Harrison Wilton
* Leslie Grossman as Meadow Wilton
* Colton Haynes as Detective Samuels
* Cheyenne Jackson as Dr. Rudy Vincent
* Adina Porter as Beverly Hope
* Billie Lourd as Winter Anderson
* Cameron Cowperthwaite as Oz Mayfair-Richards
* Emma Roberts as Serena Belinda
Season 8 (Apocalypse)
* Sarah Paulson as Cordelia Goode / Wilhemina Venable
* Evan Peters as Tate Langdon / Mr. Gallant
* Kathy Bates as Miriam Mead / The Butcher
* Emma Roberts as Madison Montgomery
* Taissa Farmiga as Zoe Benson
* Leslie Grossman as Coco St. Pierre Vanderbilt
* Billy Eichner as Brock
* Cheyenne Jackson as John Henry Moore
* Adina Porter as Dinah Stevens
* Cody Fern as Michael Langdon
* Jessica Lange as Constance Langdon