What epicdemic killed over thousand of people in London during shakespeare time there?

The bubonic plague, also known as the Black Death, was the most devastating pandemic in human history, resulting in the deaths of an estimated 75 to 200 million people in Eurasia and peaking in Europe in the 14th century. The plague reached England in 1348 and had a profound impact on the country, killing an estimated one-third of the population, including many in London.