1. The Appearance of the Ghost: After murdering Duncan, Macbeth begins to experience guilt and hallucinations, including seeing the ghost of Banquo. The ghost's appearance is a manifestation of Macbeth's inner turmoil and guilt.
2. Sleepless Nights: Both Macbeth and Lady Macbeth suffer from insomnia and disturbed sleep. Lady Macbeth becomes physically ill due to her guilt and constantly re-enacts the murder in her sleep.
3. Withdrawal and Isolation: Macbeth and Lady Macbeth become increasingly isolated from their surroundings. They withdraw from social interactions and are preoccupied with their guilt and fear of discovery.
4. Seeking Validation: Macbeth seeks validation for his actions by consulting the witches and trying to manipulate the prophecies to his advantage. However, these attempts only deepen his guilt and sense of doom.
5. Hallucinations and Madness: Macbeth's guilt manifests in the form of hallucinations and moments of madness. He sees visions of daggers and hears voices, indicating his psychological breakdown.
6. Deterioration of Relationships: The guilt of their actions drives a wedge between Macbeth and Lady Macbeth. Their relationship becomes strained as they struggle to cope with their guilt individually.
7. Mental and Physical Exhaustion: Macbeth and Lady Macbeth become physically and mentally exhausted as the weight of their guilt takes its toll. Lady Macbeth's eventual descent into madness is a direct result of her guilt.
8. Loss of Control: Macbeth's desperate attempts to maintain control over his actions and destiny only highlight his loss of control over his life. His rash decision-making and erratic behavior are evidence of his guilt-ridden state.
9. Symbolic Motifs: Shakespeare uses symbolic motifs such as blood and water to represent the guilt of Macbeth and Lady Macbeth. The blood on their hands symbolizes the stain of murder that cannot be washed away.
10. Confessions and Revelations: Eventually, both Macbeth and Lady Macbeth confess their guilt, recognizing the depths of their actions and their inability to escape the consequences of their crimes.
These pieces of evidence collectively point to the profound guilt felt by Macbeth and Lady Macbeth, which ultimately leads to their downfall and destruction.