Movies:
* Tamil:
* Kutti (2001)
* Kaadhal (2004)
* Eeram (2009)
* Aadukalam (2011) - Won Filmfare Award for Best Supporting Actor
* Vaanam (2011)
* Kumki (2012)
* Neram (2013)
* Theeya Velai Seiyyanum Kumaru (2013)
* Naan (2012)
* Meagamann (2014)
* Saivam (2014)
* Maya (2015)
* Idhu Namma Aalu (2016)
* Kavalai Vendam (2016)
* Irumbu Thirai (2018)
* Maayavan (2017)
* Kaala (2018)
* Petta (2019)
* Bigil (2019)
* Master (2021)
* Annaatthe (2021)
* Etharkkum Thunindhavan (2022)
* Maamanithan (2023)
* Vendhu Thanindhathu Kaadu (2022)
* Telugu:
* Oka Raju Oka Rani (2004)
* Arya (2004)
* Nijam (2005)
* Aadavari Matalaku Ardhalu Verule (2007)
* Jyothi (2008)
* Gamyam (2008)
* Saroja (2008)
* Pandem Kodi (2010)
* Dookudu (2011)
* Seethamma Vakitlo Sirimalle Chettu (2013)
* Gabbar Singh (2012)
* Aagadu (2014)
* Sarrainodu (2016)
* Khaidi No 150 (2017)
* Rangasthalam (2018)
* F2: Fun and Frustration (2019)
* Ala Vaikunthapurramuloo (2020)
Television:
* Tamil:
* Kutti (2001) - TV series based on the movie of the same name
* Ninaithathu Yaarumillai (2008) - TV series
* Mr & Mrs. (2013) - TV series
Sampath Raj has also appeared in a number of short films and web series. He is considered one of the most versatile and talented actors in the South Indian film industry, and is known for his ability to portray a wide range of characters with ease.
Please note that this is not an exhaustive list and there may be other projects he has been involved in.