Film:
* The Last of the Mohicans (1992) - Cora Munro
* Dark City (1998) - Emma Murdoch
* Mulholland Drive (2001) - Rita
* The Triangle (2009) - Jess
* The Woman in Black (2012) - Jean Hoggett
* The Frozen Ground (2013) - Cindy Paulson
* The Girl on the Train (2016) - Anna Boyd
Television:
* Home and Away (1993-1996) - Angel Parrish
* Friends (2000) - Rachel Green's rival
* Alias (2001-2006) - Lauren Reed
* Grey's Anatomy (2007) - Dr. Sadie Harris
* The Slap (2011) - Rosie
* Hunted (2012) - Sam Hunter
* The Good Wife (2014-2015) - Robyn Burdine
* In the Flesh (2013-2014) - Mary
* The Handmaid's Tale (2017-2018) - Mrs. Winslow
* The Flight Attendant (2020-present) - Cassie Bowden
* The Cleaning Lady (2022-present) - Thony De La Rosa
This is not an exhaustive list, but it highlights some of Melissa George's most popular and critically acclaimed work. She has shown her versatility by taking on diverse roles in different genres, and she continues to be a respected figure in the entertainment industry.