Movies:
* The Big Hit (1998) - as Katie
* The 6th Day (2000) - as Dr. Elizabeth 'Beth' McKenna
* The Art of War (2000) - as Alice
* The Negotiator (1998) - as Nina Diaz
* The Last Stand (2013) - as Helen
* The Day After Tomorrow (2004) - as Dr. Lucy Hall
* The River Wild (1994) - as Terry
* A Very Long Engagement (2004) - as the Bride's mother
* The Assignment (2016) - as Dr. Margaret
* The One (2001) - as Dr. Evelyn Stewart
Television:
* 24 (2001-2010) - as Teri Bauer
* The Dead Zone (2002-2007) - as Sarah Bracknell
* The Firm (2011-2012) - as Suzanne Wyatt
* The X-Files (1993-2002, 2016) - as Samantha "Sam" Mulder
* The 4400 (2004-2007) - as Diana Skouris
* The L Word (2004-2009) - as Alice Pieszecki (recurring role)
* Cold Case (2003-2010) - as Detective Lilly Rush
* The Twilight Zone (2019) - as Alice (episode "A Traveler")
* The Good Doctor (2017-2020) - as Dr. Audrey Lim
* The Sinner (2017) - as Heather (episode "Part IV")
* The Flash (2014-2023) - as Dr. Carla Tannhauser (multiple episodes)
* The Blacklist (2013-2023) - as Dr. Susan Hargrave (recurring role)
This list includes some of her most prominent roles. She has also appeared in a number of other television shows and movies over her career.