* Nicolas Cage as Sailor Ripley
* Laura Dern as Lula Pace Fortune
* Willem Dafoe as Bobby Peru
* Diane Ladd as Marietta Fortune
* Harry Dean Stanton as John "The Colonel" Harrelson
* Crispin Glover as Dell
* Grace Zabriskie as Sister Helen
The film also features supporting roles by:
* J.E. Freeman as Chief
* Beverly D'Angelo as Shelly
* Michael Parks as Coogan
* Sam Shepard as Chief's Deputy
* Tom Waits as The Mechanic
* Don Harvey as Clyde
This cast brings a mix of established stars, character actors, and rising talents to bring David Lynch's unique vision to life.