Movies:
* The Year of the Dragon (1985) - She won an Academy Award for Best Supporting Actress for her portrayal of the transgender character, Bill.
* Dune (1984) - She played the role of the Reverend Mother Gaius Helen Mohiam, a Bene Gesserit leader.
* Silverado (1985) - She played a gambler in this Western film.
* Practical Magic (1998) - She played the role of Aunt Jet, one of the aunts who raise the main characters.
* The Fourth Kind (2009) - She played a psychiatrist investigating alien abductions.
* Stranger Than Fiction (2006) - She played a quirky librarian.
* The Big Lebowski (1998) - She played the role of the mysterious and menacing "Bunny" Lebowski, the wife of the film's antagonist.
* The Good Shepherd (2006) - She played the role of a CIA official.
* The Machine (2014) - She played the role of a programmer who works on an AI project.
* The Americans (2013-2018) - She had a recurring role as the KGB handler "Claudia," playing an older but still formidable figure.
Television:
* The Good Wife (2010-2016) - She played the role of the strong and ruthless lawyer, Diane Lockhart, for all 7 seasons.
* Carnivàle (2003-2005) - She played the role of the powerful and enigmatic Madame Sophie.
* NCIS: Los Angeles (2009-present) - She had a recurring role as Henrietta "Hetty" Lange, the head of the NCIS team, and remains a prominent character on the show.
* The Twilight Zone (2019-2020) - She guest starred in the episode "The Traveler" as a mysterious woman.
* The Blacklist (2013-present) - She appeared in a recurring role as the dangerous "Madam Reddington" in season 8.
Other Notable Appearances:
* She has done extensive voice work for both animation and video games.
* She has performed on stage and won a Tony Award for her role in the play "End of the World."
This is just a selection of her many projects, and it highlights the range of characters she has portrayed across her career. She is known for her distinctive voice, her ability to play both strong and vulnerable characters, and her commitment to her craft.