* Seth MacFarlane:
* Peter Griffin
* Brian Griffin
* Stewie Griffin
* Glenn Quagmire
* Tom Tucker (the news anchor)
* Alex Borstein:
* Lois Griffin
* Tricia Takanawa (the news reporter)
* Seth Green:
* Chris Griffin
* Mila Kunis:
* Meg Griffin
* Mike Henry:
* Cleveland Brown
* Herbert the Pervert
* Bruce (the giant chicken)
* Consuela (the maid)
Note: While the core cast remains consistent, Family Guy has a very large roster of supporting characters who are voiced by a variety of actors, including:
* Patrick Warburton: Joe Swanson
* Adam West (deceased): Mayor Adam West
* Lori Alan: Diane Simmons (the news reporter)
* Wendy Schaal: Meg's friends
* Rachael MacFarlane: Various characters
Family Guy has also featured guest stars who have voiced characters for single episodes or story arcs.