What does Macbeth feel when he says for issue have i filed my mind?

When Macbeth says "for issue have I filed my mind," he is expressing a sense of regret and shame over the consequences of his actions. He has betrayed his king and country by murdering Duncan, and he is now suffering from the guilt and paranoia that come with being a murderer. The phrase "for issue" suggests that he is now paying the price for his misdeeds, and that he will continue to suffer as a result of them.