- Dante Alighieri: Dante himself is the main character and narrator of the Divine Comedy. He is the one who is guided through the realms of Hell, Purgatory, and Paradise.
- Virgil: Virgil is a Roman poet who appears as Dante's guide through Hell and Purgatory. He symbolizes human reason and knowledge, guiding Dante through the lower realms.
- Beatrice: Beatrice is a heavenly woman who appears to Dante in Paradise. She symbolizes divine love and ultimate spiritual enlightenment.
- God: God is the ultimate figure in the Divine Comedy, representing the source of all love, wisdom, and virtue. Dante seeks to reach and understand the nature of God throughout his journey.
- Various Saints and Historical Figures: Dante also interacts with numerous saints, historical figures, and other figures from classical mythology throughout his journey. These characters often serve as guides or provide important lessons to Dante.