1. Lex Luthor: Superman's arch-nemesis, known for his intelligence and obsession with surpassing the Man of Steel.
2. Magneto: A powerful mutant with the ability to control metal, often portraying both heroic and villainous traits in the X-Men comics.
3. Thanos: A cosmic warlord and one of the most powerful beings in the Marvel universe, known for his quest to acquire the Infinity Stones.
4. Darth Vader: The iconic antagonist from the Star Wars franchise, once a noble Jedi Knight turned to the dark side, becoming the enforcer for the Galactic Empire.
5. Loki: Thor's mischievous brother and a trickster god, often causing trouble and rivaling his brother for attention and power.
6. Green Goblin: A recurring nemesis of Spider-Man, known for his iconic pumpkin bombs and glider.
7. Doctor Doom: A brilliant scientist and sorcerer from Latveria, often depicted as a rival to the Fantastic Four and a significant threat to the Marvel universe.
8. Cruella De Vil: A wealthy and eccentric villain from the 101 Dalmatians story, known for her desire to use Dalmatians' fur for her fashion creations.
9. Voldemort: The main antagonist of the Harry Potter series, a dark wizard who seeks immortality and desires to rule the wizarding world.
10. Maleficent: A powerful fairy and the antagonist in the Sleeping Beauty story, known for her ability to transform into a dragon.
These are just a few examples of many other well-known villains from various forms of popular culture. Each has unique traits, motivations, and appearances that contribute to their villainy.