The cast includes:
* Lucille Ball (archive footage)
* Desi Arnaz (archive footage)
* Katie Holmes as Lucy Ricardo (re-enacting scenes from the original series)
* Sean Hayes as Ricky Ricardo (re-enacting scenes from the original series)
* Debra Messing as Vivian Vance (re-enacting scenes from the original series)
* Wayne Brady as William Frawley (re-enacting scenes from the original series)
* Sally Jessy Raphael as herself
* Carol Burnett as herself
* Steve Allen as himself
The movie itself isn't a continuation of the original "I Love Lucy" series but rather a tribute to the show. It involves re-enacted scenes from the original series, with modern actors playing the iconic roles.