What was the name of cartoon late at night about a guy who leaves pub then gets run over and ends up in wheelchair?

You're likely thinking of the animated series "The PJs", created by Eddie Murphy.

The main character, "Curtis", is a middle-aged man who frequently leaves the local bar, only to get into misadventures. While he doesn't end up in a wheelchair, there are several instances where he suffers comedic injuries, and the show often focuses on his struggles and observations of his eccentric neighbors.

It's worth noting that the show aired on Fox, and while it was a late-night show, it wasn't as late as some other adult animated series.