* Stefan Salvatore and Damon Salvatore, the two main male leads and the heart of the show.
* Elijah Mikaelson and Klaus Mikaelson, a pair of ancient vampires who are brothers, with a complicated and often antagonistic relationship.
There are also other brothers who play a role in the series:
* Kol Mikaelson (Klaus and Elijah's brother), and Finn Mikaelson (another brother) who are also part of the Mikaelson family.
* Jeremy Gilbert, the younger brother of Elena Gilbert, who also has a connection to the vampire world.
It's important to note that there are numerous other characters in the show who have siblings, but the brothers listed above play the most significant roles in the storyline.