What was the show called that used to be on TV or Netflix had a middle-aged blonde woman with big eyes and male intern red hair. I think it about some kind of show?

You're likely thinking of the show "The Kominsky Method" starring Michael Douglas and Alan Arkin.

While the show doesn't feature a red-haired male intern, it does have a key character:

* Lisa Edelstein plays "Madeline", a successful actress who becomes romantically involved with Sandy Kominsky (Michael Douglas). Madeline has big, expressive eyes and is a middle-aged blonde woman.

Could this be the show you're looking for? Let me know if you have any other details!