However, she has a close relationship with the character of "Baby" (a chihuahua) and often refers to him as her "son." There is also a running joke about Karen having a secret daughter, named "Lisa," who is supposedly living in a mental institution. This is a long-running gag that never gets resolved and is never shown to be true.
So, while Karen doesn't have any biological children, her relationship with "Baby" and the "Lisa" gag highlight her eccentric personality and humorous quirks.