According to the most popular account, Shakespeare died of a fever. This account is based on a 17th-century biography by John Aubrey, which states that Shakespeare "died of a feavour there, and was buried in Stratford."
Some scholars have speculated that Shakespeare may have died from other causes, such as a heart attack or a stroke. However, there is no evidence to support these claims.
The exact cause of Shakespeare's death may never be known, but it is clear that he was a man of great talent and genius, and that his work has had a profound impact on literature and culture around the world.