When does macbeth begin to hope for death?

Macbeth begins to hope for death after the murder of Duncan. He feels guilty and overwhelmed by the consequences of his actions. This guilt leads him to spiral into a state of despair and self-loathing. As the play progresses, Macbeth's mental state deteriorates further, and he becomes increasingly nihilistic and callous. He eventually reaches a point where he no longer fears death and longs for it as a release from his suffering.