If you are using the instrumental for a commercial purpose, such as selling your song or releasing it on an album, you will almost certainly need to get permission from the artist or their record label. However, if you are using the instrumental for a non-commercial purpose, such as creating a fan remix, you may be able to use it without getting permission.
It is important to note that the rules surrounding copyright can be complex, and it is always best to err on the side of caution and get permission if you are unsure whether you need it.