Set the volume of the guitar to the highest volume setting. This will ensure that the guitar will send the maximum volume of sound to the amplifier.
Turn the volume knob counterclockwise until you are unable to turn it any further. Turning the volume all the way down helps to prevent blowing out your speakers.
Adjust the gain to about three-quarters of its maximum. You can do this by turning the gain knob clockwise.
Slowly increase the volume on the amplifier, by turning the volume knob clockwise, while playing the guitar until you get the right volume level for your needs.
Use a multichannel amp to quickly switch back and forth between distortion and a clean sound. Multichannel amps will have a separate volume and gain knob for each channel. To move between channels you simply depress the button for the channel you want to activate.