Frequency Response: Bass amplifiers are typically designed to emphasize low frequencies, which may not be ideal for the higher frequencies of a guitar. You may need to adjust the EQ settings on the amplifier to compensate for this, boosting the treble and reducing the bass and mids.
Speaker Size and Cabinet Design: Bass amps often have larger speakers and cabinets than guitar amps, which can produce a fuller, warmer sound. However, this may not be necessary or desirable for guitar, which benefits from a tighter, more articulate sound. If the bass amp has a tweeter or adjustable EQ, you can use these to balance the frequency response for guitar.
Power Handling: Bass amplifiers typically have higher power ratings than guitar amps, which is necessary to drive the larger speakers and produce the lower frequencies of bass. This can be an advantage for guitar if you need a lot of volume or headroom, but it may also be overkill for smaller gigs or practice sessions.
Overall Tone: The overall tone of a bass amplifier may be different from what you are used to with a guitar amplifier, due to the differences in frequency response, speaker size, and cabinet design. You may need to experiment with different settings and techniques to find a sound that works for you.
Ultimately, whether or not a Laney HCM65B bass amplifier works well for your standard 6-string electric guitar is a matter of personal preference and the specific sound you are trying to achieve. If you are looking for a versatile amplifier that can be used for both bass and guitar, the HCM65B may be a good option. However, if you are primarily a guitar player, you may be better off with a guitar-specific amplifier.