While Lucille Ball was a successful radio actress, the premise for "I Love Lucy" came from the comedic adventures and challenges they faced as a couple. The show borrowed heavily from their relationship dynamics, turning their real-life experiences into hilarious situations.
The show's success was largely due to the chemistry between Lucille Ball and Desi Arnaz, their on-screen marriage mirrored the real-life love and comedy they shared. So, while not directly based on a radio show, "I Love Lucy" was very much rooted in Lucille Ball's own life and the real-life comedic dynamic of her marriage.