- My Morning Jacket: Formed in 1998 in Louisville, My Morning Jacket is known for their distinctive indie rock sound. They have released several acclaimed albums, including "Z," "Evil Urges," and "Circuital."
- Cage the Elephant: Hailing from Bowling Green, Cage the Elephant gained attention with their 2008 self-titled debut album, which featured the hit single "Ain't No Rest for the Wicked." They have since released several successful albums and won a Grammy Award for Best Rock Album for their 2016 album, "Tell Me I'm Pretty."
- White Reaper: Formed in Louisville, White Reaper is a garage rock band known for their energetic live performances and catchy songs. They have released several well-received albums, including "White Reaper Does It Again" and "You Deserve Love."
- The Whipsaws: This Lexington-based band was active in the 1980s and gained a following for their cowpunk sound. They released several albums, including "Beat on the Brat" and "That's What Life's About."
- The Judybats: Formed in Louisville in the early 1990s, The Judybats are known for their mix of garage rock, punk, and power pop. They released several albums, including "Native Son" and "Jigsaw."
- Slint: Hailing from Louisville, Slint is considered one of the pioneers of post-rock music. Their influential 1991 album, "Spiderland," is widely regarded as a classic of the genre.