- B.B. King: Known as the "King of the Blues", B.B. King is considered one of the greatest blues musicians of all time. His soulful guitar playing and powerful vocals made him a legend of the genre.
- Robert Johnson: A highly influential blues musician, Robert Johnson is known for his raw and haunting Delta blues sound. Despite his short career, Johnson's music had a profound impact on the development of blues and rock music.
- Muddy Waters: Often referred to as the "Father of Modern Chicago Blues", Muddy Waters was a major figure in the post-World War II blues scene. His music blended traditional Delta blues with electric guitar and urban sounds.
- Howlin' Wolf: Known for his powerful, gritty vocals and intense stage presence, Howlin' Wolf was a prominent blues artist in Chicago. His music is characterized by its raw emotional expression and strong rhythms.
- Bessie Smith: Dubbed the "Empress of the Blues", Bessie Smith was one of the most successful blues singers of the 1920s and 1930s. Her powerful voice and emotive performances made her a beloved figure in the blues community.
- John Lee Hooker: John Lee Hooker's distinctive guitar style and mesmerizing vocal delivery made him one of the most recognizable figures in blues music. He is known for his repetitive rhythmic patterns known as "the boogie."
- Buddy Guy: A prominent Chicago blues guitarist and singer, Buddy Guy is renowned for his electrifying performances and exceptional guitar skills. He is considered one of the last living legends of the blues.
- Son House: A key figure in the early Delta blues movement, Son House is known for his intense, almost hypnotic guitar playing and deep, resonant vocals. His music greatly influenced later generations of blues musicians.
- Willie Dixon: While not primarily a performer, Willie Dixon was a songwriter, bassist, and producer who made significant contributions to the Chicago blues scene. He is known for writing numerous classic blues songs recorded by various artists.
- Big Mama Thornton: Big Mama Thornton was a powerful vocalist who gained fame in the 1950s. Her rendition of "Hound Dog" preceded Elvis Presley's hit version and is considered an essential blues classic.