* Doug Heffernan: Played by Kevin James, Doug is a delivery man who is lazy, lovable, and often gets into trouble.
* Carrie Heffernan: Played by Leah Remini, Carrie is Doug's wife, who is practical, sarcastic, and often exasperated by her husband's antics.
* Arthur Spooner: Played by Jerry Stiller, Arthur is Doug's father-in-law, who is eccentric, manipulative, and often gives Doug bad advice.
* Deacon Palmer: Played by Victor Williams, Deacon is Doug's best friend, who is laid-back, supportive, and often involved in Doug's schemes.
There are also many recurring characters who appear throughout the series, such as:
* Spencer: Doug's boss, who is a demanding and grumpy man.
* Patty: Carrie's mother, who is more level-headed than Arthur.
* Rikki: Doug's sister, who is a free-spirited and often irresponsible woman.
* Danny: Doug and Carrie's son, who grows up over the course of the series.