- Ian Beale (played by Adam Woodyatt) has been married four times throughout the show's history. His first wife was Cindy Williams (Michelle Collins), whom he married in 1983. They had one child together, Lucy Beale (Hetti Bywater). Ian's second wife was Melanie Owen (Tamzin Outhwaite), whom he married in 1999. They had one child together, Kirsty Mitchell (Kierston Wareing). Ian's third wife was Glenda Mitchell (Glynis Barber), whom he married in 2010. They did not have any children together. Ian's fourth wife was Sharon Watts (Letitia Dean), whom he married in 2016. They did not have any children together.
- Phil Mitchell (played by Steve McFadden) has been married three times throughout the show's history. His first wife was Kathy Beale (Gillian Taylforth), whom he married in 1990. They had one child together, Ben Mitchell (Charlie Jones). Phil's second wife was Lisa Fowler (Lucy Benjamin), whom he married in 1998. They did not have any children together. Phil's third wife was Sharon Watts (Letitia Dean), whom he married in 2001. They had one child together, Dennis Rickman (Bleu Landau).
- Alfie Moon (played by Shane Richie) has been married three times throughout the show's history. His first wife was Kat Slater (Jessie Wallace), whom he married in 2003. They had two children together, Tommy Moon (Shaheen Jafargholi) and Bert Moon (Freddie Phillips). Alfie's second wife was Roxy Mitchell (Rita Simons), whom he married in 2010. They did not have any children together. Alfie's third wife was Kat Slater (Jessie Wallace), whom he remarried in 2016. They did not have any children together.
- Jack Branning (played by Scott Maslen) has been married twice throughout the show's history. His first wife was Rachel Branning (Amy Robbins), whom he married in 2010. They did not have any children together. Jack's second wife is Ronnie Mitchell (Samantha Womack), whom he married in 2015. They had one child together, Matthew Mitchell-Cotton (Jack Derges).
- Max Branning (played by Jake Wood) has been married three times throughout the show's history. His first wife was Tanya Cross (Jo Joyner), whom he married in 1996. They had one child together, Abi Branning (Lorna Fitzgerald). Max's second wife was Stacey Slater (Lacey Turner), whom he married in 2007. They had one child together, Lily Slater (Lillia Turner). Max's third wife was Kirsty Branning (Kierston Wareing), whom he married in 2014. They did not have any children together.