* Susan Kennedy (played by Jackie Woodburne)
* Karl Kennedy (played by Alan Fletcher)
* Paul Robinson (played by Stefan Dennis)
* Terese Willis (played by Rebekah Elmaloglou)
* Leo Tanaka (played by Tim Kano)
* David Tanaka (played by Takaya Honda)
* Aaron Brennan (played by Matt Wilson)
* David Tanaka's partner, Aaron Brennan, is a nurse and the adoptive father of Abigail Tanaka.
* Leo's younger brother, David Tanaka, is a doctor and in a relationship with Leo.
* Paul Robinson is a wealthy businessman and the owner of Lassiter's Hotel. He is also the father of Terese Willis and grandfather of Isla Willis.
* Terese Willis is the manager of Lassiter's Hotel and the mother of Isla Willis.
* Sheila Canning (played by Cosima De Vito)
* Kyle Canning (played by Chris Milligan)
* Roxy Willis (played by Zima Anderson)
* Amy Greenwood (played by Zoe Cramond)
* Ned Willis (played by Ben Hall)
* Harlow Robinson (played by Jemma Donovan)
* Mackenzie Hargreaves (played by Georgie Stone)
* Chloe Brennan (played by April Rose Pengilly)
* Nicolette Stone (played by Charlotte Chimes)
Other characters include:
* Toadie Rebecchi (played by Ryan Moloney)
* Sonya Mitchell (played by Eve Morey)
* Steph Scully (played by Carla Bonner)
* Mark Brennan (played by Scott Major)
* Tyler Brennan (played by Travis Burns)
* Piper Willis (played by Mavournee Hazel)
* Tyler Brennan's ex-wife, Piper Willis, is a lawyer and the mother of Tyler's daughter, Mackenzie Hargreaves.
* Tyler's brother, Mark Brennan, is a police officer.
* Steph Scully is a chef and the owner of The Waterhole.
* Sonya Mitchell is a nurse and Toadie's wife.
* Toadie Rebecchi is a lawyer and the adoptive father of Willow Harris and Hugo Somers.
Several other characters have also appeared on the show over the years, including:
* Madge Bishop (played by Anne Charleston)
* Harold Bishop (played by Ian Smith)
* Jim Robinson (played by Alan Dale)
* Annalise Hartman (played by Kimberley Davies)
* Lou Carpenter (played by Tom Oliver)
* Cheryl Stark (played by Caroline Gillmer)
* Scott Robinson (played by Jason Donovan)
* Charlene Robinson (played by Kylie Minogue)
* Mike Young (played by Guy Pearce)
* Bouncer Barnes (played by Natalie Imbruglia)