10+ Seasons
* "The Simpsons" (35 seasons) - The longest-running American animated sitcom, known for its satirical humor and iconic characters.
* "Gunsmoke" (20 seasons) - A Western series, it was the longest-running American dramatic series, though it had some comedic elements.
* "The Adventures of Ozzie and Harriet" (14 seasons) - A wholesome sitcom about a family's everyday life, known for its portrayal of 1950s American life.
* "I Love Lucy" (6 seasons) - A classic sitcom that redefined the genre with its physical comedy and iconic characters.
* "The Andy Griffith Show" (8 seasons) - A heartwarming sitcom about life in a small town, known for its relatable characters and gentle humor.
* "Cheers" (11 seasons) - A bar-set sitcom that became a cultural phenomenon, known for its witty dialogue and ensemble cast.
* "Frasier" (11 seasons) - A spin-off of "Cheers", featuring a psychiatrist and his family, known for its clever writing and sophisticated humor.
* "Friends" (10 seasons) - A beloved sitcom about six friends living in New York City, known for its relatable storylines and iconic characters.
* "Seinfeld" (9 seasons) - A groundbreaking sitcom that revolutionized television comedy with its cynical humor and focus on everyday situations.
* "The Golden Girls" (7 seasons) - A popular sitcom about four older women living together, known for its witty dialogue and heartwarming stories.
* "Everybody Loves Raymond" (9 seasons) - A family sitcom focusing on the relationship between a sportswriter and his overbearing mother, known for its relatable humor and strong characters.
* "Will & Grace" (11 seasons) - A sitcom about two best friends, one gay and one straight, known for its witty dialogue and groundbreaking portrayal of gay characters.
* "Modern Family" (11 seasons) - A mockumentary-style sitcom that explored the complexities of family life in the 21st century, known for its diverse characters and heartwarming stories.
8-9 Seasons
* "The Cosby Show" (8 seasons) - A groundbreaking sitcom that focused on an African American family, known for its heartwarming stories and relatable characters.
* "Home Improvement" (8 seasons) - A sitcom about a handyman and his family, known for its slapstick humor and relatable situations.
* "Married... with Children" (11 seasons) - A controversial sitcom that satirized the American family, known for its irreverent humor and edgy storylines.
* "Roseanne" (9 seasons) - A blue-collar sitcom that depicted the everyday life of a working-class family, known for its realistic portrayal of family struggles and its sharp social commentary.
* "King of the Hill" (13 seasons) - An animated sitcom that satirized life in a small Texas town, known for its relatable characters and its exploration of social issues.
This is just a small sampling of the many long-running US sitcoms that have entertained audiences for generations. There are many other noteworthy shows that deserve to be mentioned, such as "The Mary Tyler Moore Show," "M*A*S*H," "Family Ties," "The Fresh Prince of Bel-Air," "King of Queens," and "Two and a Half Men."