* Aissa Wayne (born 1932) appeared in several films, most notably alongside her father in "Big Jake" (1971) and "The Shootist" (1976).
* Ethan Wayne (born 1962) acted in several films throughout the 1980s and 1990s, including "The Legend of Walks Far Woman" (1982) and "The Alamo: 13 Days to Glory" (1987).
While other children of John Wayne may have had some involvement in the film industry in other roles, only Aissa and Ethan had acting careers.