* Patrick Wayne: He had a long acting career, appearing in over 70 films and television series. Some of his most notable roles include:
* The Green Berets (1968)
* Big Jake (1971) - alongside his father John Wayne
* The Shootist (1976) - alongside his father John Wayne
* McQ (1974)
* The Wild Geese (1978)
* The Towering Inferno (1974)
* The Island at the Top of the World (1974)
* The Searchers (1956) - uncredited as a child actor
* Ethan Wayne: Primarily worked as a stuntman, but also appeared in a few films, including:
* Big Jake (1971)
* The Shootist (1976) - alongside his father John Wayne
* McQ (1974)
* Michael Wayne: Worked as a film producer, but also appeared in a few films, including:
* The Green Berets (1968)
* Big Jake (1971) - alongside his father John Wayne
* John Wayne (Jr.): He was adopted by John Wayne and his wife, but ultimately pursued a career outside of the film industry.
While John Wayne's sons were not all major stars, several of them worked in the film industry and appeared in films alongside their father. They also carried on the Wayne family legacy in different ways.