Live-Action:
* The Birdcage (1996) - as Agador Spartacus
* Godzilla (1998) - as Victor "Vic" Palucci
* Mystery Men (1999) - as The Spleen
* America's Sweethearts (2001) - as Glen
* The Emperor's Club (2002) - as Mr. Hundert
* Along Came Polly (2004) - as Sandy Lyle
* Night at the Museum (2006) - as Cecil Fredericks
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* Marley & Me (2008) - as John Grogan
* The Smurfs (2011) - as Grouchy Smurf (voice)
* The Smurfs 2 (2013) - as Grouchy Smurf (voice)
* The Smurfs: The Lost Village (2017) - as Grouchy Smurf (voice)
* The Grand Budapest Hotel (2014) - as M. Ivan
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
Animation:
* The Simpsons (1989-present) - as Homer Simpson, Apu Nahasapeemapetilon, Moe Szyslak, Chief Wiggum, Carl Carlson, and many other characters (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Smurfs (2011) - as Grouchy Smurf (voice)
* The Smurfs 2 (2013) - as Grouchy Smurf (voice)
* The Smurfs: The Lost Village (2017) - as Grouchy Smurf (voice)
* Ice Age: Continental Drift (2012) - as Squint (voice)
* The Lego Movie (2014) - as President Business (voice)
* The Lego Batman Movie (2017) - as Alfred Pennyworth (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
* The Simpsons Movie (2007) - as Homer Simpson (voice)
This is not an exhaustive list, but it includes some of his most notable film roles.