Movies:
* The Fog (1980) - Stevie Wayne
* Escape from New York (1981) - Maggie
* Creepshow (1982) - Billie
* The Last Unicorn (1982) - Molly Grue
* Swamp Thing (1982) - Alice Cable
* The Cannonball Run (1981) - Marcie
* Back to School (1986) - Valerie
* The Blob (1988) - Debbie
* The Kiss (1988) - Sarah
* The Godfather: Part III (1990) - Mrs. Mancini
* The Haunted Mansion (2003) - The Ghost Host (voice)
* Halloween (2007) - Dr. Loomis (voice)
* The Grudge 3 (2009) - Aunt Evelyn
* The Woman (2011) - Doris
* The Last Exorcism (2010) - Cote
* The Devil's Carnival (2012) - The Ringmaster
* The Purge (2013) - Mrs. Sandin
* The Neighbor (2012) - Mrs. Peterson
* Killer Joe (2011) - Charlene
* The Super (2011) - Mrs. Garcia
* The Devil's Due (2014) - Sister Angela
* The Domestics (2018) - Nina
Television:
* Maude (1972-1978) - Carol
* Happy Days (1974-1984) - Pinky Tuscadero
* Carnivàle (2003-2005) - Sofie
* Arrested Development (2003-2006) - Lucille Bluth (voice)
* Supernatural (2005-2020) - The First Blade
* The Following (2013-2015) - Clara
* Chicago Fire (2012-present) - Chief Boden's wife, Donna
* The Orville (2017-present) - Dr. Claire Finn
This is just a selection of her work. Adrian Barbeau has a long and successful career in film and television.