Movies:
* "Street Days" (2010): Tsulukidze starred in this Georgian drama film as one of the main characters, Lizi.
* "Piranesi" (2011): She played the leading role of Laura in this Georgian drama set in Batumi.
* "Keep Smiling" (2012): Tsulukidze appeared in this Georgian comedy-drama.
* "Corn Island" (2014): She had a supporting role in this Georgian drama.
* "Brides" (2014): Tsulukidze played one of the main characters, Dina, in this Georgian-French co-production.
* "Hostages" (2017): She had a role in this Georgian drama film.
* "And Then We Danced" (2019): Tsulukidze portrayed Merab's friend and dance partner, Mary, in this internationally acclaimed Georgian drama about ballroom dancing.
* "Beginning" (2020): She played the leading role of Yana in this Georgian drama following a woman trying to start over while facing societal challenges.
Television:
* "Tskhovreba da tsiteli mtatsminda" (2014): Tsulukidze had a lead role in this Georgian television series.
* "Me kvriv rodesac shemovkinaot" (2018): She appeared in this Georgian television series.
* "Mshvidobis Sakme" (2020-2021): Tsulukidze played one of the leading roles, Tamara, in this ongoing Georgian television series about four friends navigating personal and professional challenges.
Apart from acting, Megi Tsulukidze has also directed and produced independent short films and documentaries. These projects showcase her involvement in various aspects of filmmaking beyond performing in front of the camera.