* 1991: Livin' Large as Kim
* 1995: Waiting to Exhale as Robin Stokes
* 1996: Set It Off as Stony
* 1997: Eve's Bayou as Mozelle Baptiste
* 1997: Soul Food as Faith Rivers
* 1998: Brown Sugar as Sydney 'Syd' Shaw
* 2000: Love & Basketball as Camille Wright
* 2002: The Perfect Score as Anna Ross
* 2003: The Matrix Reloaded as Lilo'ah
* 2003: The Matrix Revolutions as Lilo'ah
* 2003: Malibu's Most Wanted as Shondra
* 2004: The Woodsman as Roberta
* 2005: Get Rich or Die Tryin' as Charlene
* 2006: Fast Track as Maya Hayes
* 2008: City of Ember as Clary
* 2009: Traitor as Mrs. Carter
* 2012: Midnight's Children as Amina Sinai
* 2012: 13 Moons as Rae Thomas
* 2014: 13 Sins as Sheila Remington
* 2016: Smartass as Detective Amanda Taylor
* 2017: Resident Evil: The Final Chapter as Colette
* 2019: Motherless Brooklyn as Laura Rose
Television series
* 1991: Thea as Theresa 'Thea' Tatum
* 1993: In the Heat of the Night as Dana Robinson
* 1995: Murder One as Detective Sharon Reeves
* 1997: Ally McBeal as Lisa Knowles
* 2002–2003: Girlfriends as Joan Clayton
* 2005: Lackawanna Blues as Bernadine 'Bernie' Brown
* 2005: Gone but Not Forgotten as Det. Noreen Tyler
* 2005–2006: The L Word as Tasha Williams
* 2008: Lipstick Jungle as Wendy Healy
* 2009: Washington Field as Agent Carrie Wells
* 2012–2013: Chase as Agent Daisy Ogbaa
* 2015: Empire as Kelly Patel
* 2015: Rosewood as Detective Donna Rosewood
* 2015: Criminal Minds: Beyond Borders as Special Agent Nicole Henry
* 2015–2016: The Catch as Valerie Anderson
* 2018: The Purge as Michelle Moore
* 2019: The Enemy Within as Dani Forester
* 2022: For All Mankind as Aleida Rosales
* 2022: The Lincoln Lawyer as Lara Ernst