Movies:
* Paper Heart (2009): As herself, playing a fictionalized version of her life.
* This Is 40 (2012): As Sadie, a quirky friend of the main character.
* The Sitter (2011): As the slightly crazy neighbor, Brenda.
* The Disaster Artist (2017): As a fictionalized version of herself, an actress in the film "The Room".
* The House (2017): As a mysterious "girl with the tattoo", providing a voice-over for the main character's hallucinations.
* The Afterparty (2022): As Detective Danner, a quirky detective investigating a murder.
* Good Luck to You, Leo Grande (2022): As a young woman who has sex with the titular character.
Television:
* House (2007-2012): Recurring role as Dr. Tran.
* The Sarah Silverman Program (2007-2010): As various characters.
* The Big Bang Theory (2010): As a fictionalized version of herself.
* Adventure Time (2010-2018): Voice role as Huntress Wizard.
* The Office (2012): As a fictionalized version of herself.
* Forever (2014-2015): As a psychic medium.
* The Mindy Project (2014): As a friend of Mindy.
* Maron (2016): As herself.
* The Goldbergs (2017): As a guest star.
* Space Force (2020): As Dr. Chan.
* Young Rock (2021): As a guest star.
* Never Have I Ever (2021): As a therapist.
This is just a sampling of her work. Charlyne Yi is a very active performer and has appeared in many other projects as well. She continues to build a varied and impressive resume.