Movies:
* Scream (1996): His breakout role as Dewey Riley, a lovable but somewhat bumbling deputy. He reprised the role in the sequels *Scream 2 (1997)*, *Scream 3 (2000)*, *Scream 4 (2011)*, and *Scream (2022)*.
* Never Been Kissed (1999): He played the love interest of Drew Barrymore's character.
* Eight Legged Freaks (2002): He starred as a small-town sheriff dealing with giant spiders.
* The Tripper (2006): He played a serial killer, a departure from his typical roles.
* Marigold (2007): He directed and starred in this drama.
* The Butler (2013): He played a supporting role in this historical drama.
* Zoolander 2 (2016): He had a small but memorable role as a fashion designer.
* Death of a Cheerleader (2017): He directed this comedy-horror film.
Television:
* Friends (1996): He played a recurring role as a man who briefly dates Phoebe.
* Cougar Town (2009-2015): He had a major role as the husband of Courteney Cox's character.
* Celebrity Ghost Stories (2011-2013): He hosted this paranormal series.
* The Osiris Child: Science Fiction Volume One (2016): He starred in this science fiction film.
* The Loud House (2016-present): He voices a recurring character, a rock star.
* The Guest List (2022): He had a main role in this British crime drama series.
Other notable projects:
* David Arquette: Chasing Ghosts (2022): A documentary about his struggles with addiction and his journey to sobriety.
Note: This is not an exhaustive list, but it includes some of his most prominent and well-known projects.