Television:
* Who's the Boss? (1984-1992): This iconic sitcom launched her career and made her a household name. She played Samantha Micelli, the daughter of a single mother who worked as a housekeeper for a wealthy bachelor.
* Commando (1985): She appeared in this action film alongside Arnold Schwarzenegger.
* The Charmings (1991-1992): She starred in this short-lived sitcom.
* Melrose Place (1992-1999): Played the role of the ambitious and sometimes ruthless Samantha Micelli in this popular drama series.
* Charmed (1998-2006): This fantasy-drama series was a major hit. Milano played Phoebe Halliwell, one of three sisters who discover they are witches.
* My Name Is Earl (2005-2009): She guest-starred in this comedy series as a love interest for the main character.
* Mistresses (2013-2016): Milano starred as Savannah Davis in this drama series about four friends navigating love and relationships.
* Insatiable (2018): She played the role of a cynical lawyer in this controversial Netflix series.
* Wet Hot American Summer: First Day of Camp (2015): She reprised her role as the iconic "Counselor Lindsay" from the original "Wet Hot American Summer" film.
* Insomnia (2002): She guest-starred in this crime drama series.
Movies:
* Commando (1985): As mentioned above, she appeared in this action film alongside Arnold Schwarzenegger.
* The Right Stuff (1983): Played a supporting role in this biographical drama.
* The Surrogate (1985): She starred in this psychological thriller.
* The New Hooker (1985): Appeared in this controversial drama.
* Like Father Like Son (1987): Played a supporting role in this comedy.
* The Canterville Ghost (1989): She starred in this horror comedy.
* Little Sister (1990): Appeared in this drama.
* The Little Sister (1990): She starred in this thriller.
* The Storyteller (1994): Appeared in this romantic drama.
* Fear (1996): Played a supporting role in this horror film.
* Poison Ivy: The New Seduction (1997): She starred in this thriller.
* Hall Pass (2011): Appeared in this comedy film.
* The Secret Life of the American Teenager (2008): She had a voice role in this teen drama.
* The Little Things (2021): She appeared in this crime thriller alongside Denzel Washington and Rami Malek.
* The Princess Switch (2018): She starred in this popular Christmas movie on Netflix alongside Vanessa Hudgens.
* The Princess Switch: Switched Again (2020): She reprised her role in this sequel to "The Princess Switch."
This list is not exhaustive, but it includes some of her most notable roles. She has also had guest appearances in various other television shows and movies over the years.