Movies:
* The Tommy Dorsey Story (1956): Her film debut, playing the role of singer and actress Helen O'Connell.
* The Big Knife (1955): As Charles Laughton's mistress.
* The Virginian (1962): In a role as a teacher who is drawn into a conflict with the locals.
* The Spiral Road (1962): A French-American co-production, playing a Vietnamese woman.
* The Pawnbroker (1965): As a young woman who seeks out her brother, the pawnbroker, played by Rod Steiger.
* The Swimmer (1968): A drama starring Burt Lancaster, Douglas plays a woman who had a long affair with the protagonist.
* The Baby Maker (1970): In a starring role as a woman who takes the unconventional route to motherhood.
* The Apprenticeship of Duddy Kravitz (1974): As the mother of the protagonist, Duddy.
* The Changeling (1980): A horror film, Douglas plays the role of a social worker.
* The Last Starfighter (1984): As the mother of the protagonist.
* The Peanut Butter Solution (1985): Playing a role as a psychiatrist.
* Deadwood (2004): Her last film role as a saloon owner.
Television:
* The Twilight Zone (1961): Appeared in the episode "The Shelter."
* Bonanza (1962): In a guest appearance in the episode "The Last Ride."
* The Fugitive (1963): Played a woman who helps the fugitive.
* The Man from U.N.C.L.E. (1964): In the episode "The Concrete Jungle."
* The Wild Wild West (1965): Appeared in the episode "The Night of the Howling Dogs."
* The Virginian (1965): Multiple appearances over the course of the show's run.
* The Mod Squad (1969): In the episode "The Long Way Home."
* The F.B.I. (1970): In the episode "The Last Ride."
* The Love Boat (1978): In the episode "The Homecoming."
* The Hitchhiker (1984): In the episode "The Man Who Didn't Like Women."
* The Equalizer (1987): In the episode "The Confession."
* The X-Files (1995): In the episode "The Pine Bluff Variant."
* The Outer Limits (1995): In the episode "The Voyage Home."
* ER (1996): In a recurring role as a patient in the psychiatric ward.
* The Practice (1998): In the episode "The Verdict."
* ReGenesis (2004): Her final television role as a scientist.
This list represents just a selection of Shirley Douglas's extensive work. She was known for her versatility and commitment to her craft, appearing in a wide range of genres, including dramas, thrillers, and comedies.