Movies:
* Star Wars franchise (1977-present) as Luke Skywalker (all nine films)
* Corvette Summer (1978) as Ken Roberts
* The Big Red One (1980) as Private Griff
* The Man with One Red Shoe (1985) as Detective Jake 'The Torch' Foley
* The Princess Bride (1987) as The Invincible Man
* Batman: The Killing Joke (2016) as The Joker (voice)
* Star Wars: The Last Jedi (2017) as Luke Skywalker
* The Lego Movie 2: The Second Part (2019) as The Green Lantern (voice)
* Jay and Silent Bob Reboot (2019) as himself
* The Mandalorian (2019-2023) as Luke Skywalker (voice)
* The Book of Boba Fett (2022) as Luke Skywalker (voice)
* The Flash (2023) as The Joker (uncredited)
Television:
* General Hospital (1978-1981) as Dr. David Collins
* The Super Mario Bros. Super Show! (1989-1990) as Mario (voice)
* Batman: The Animated Series (1992-1995) as The Joker (voice)
* Superman: The Animated Series (1996-2000) as The Joker (voice)
* The Simpsons (1991-present) as various characters (voice)
* The X-Files (1996) as Agent Donnie Pfaster
* The Simpsons (1991-present) as various characters (voice)
* Star Wars: The Clone Wars (2008-2020) as Jedi Master Luke Skywalker (voice)
* Robot Chicken (2005-present) as various characters (voice)
* Star Wars Rebels (2014-2018) as Jedi Master Luke Skywalker (voice)
* The Flash (2014-present) as The Trickster
* Teen Titans Go! (2013-present) as The Joker (voice)
* Harley Quinn (2019-present) as The Joker (voice)
* The Mandalorian (2019-2023) as Luke Skywalker (voice)
* What We Do in the Shadows (2019-present) as Guillermo's Father (voice)
* Star Wars: Visions (2021) as The Elder (voice)
* Young Justice (2010-present) as The Joker (voice)
* Star Wars: Tales of the Jedi (2022) as Luke Skywalker (voice)
* The Book of Boba Fett (2022) as Luke Skywalker (voice)
* The Bad Batch (2021-present) as Jedi Master Luke Skywalker (voice)
* Star Wars: Resistance (2018-2020) as Jedi Master Luke Skywalker (voice)
* Star Wars: Forces of Destiny (2017-2018) as Luke Skywalker (voice)
* The Last Jedi: A Star Wars Story (2017) as Luke Skywalker (voice)
* The Rise of Skywalker: A Star Wars Story (2019) as Luke Skywalker (voice)
This is not an exhaustive list, but it covers some of Mel Hamill's most notable and memorable projects. He has a very active career in both film and television, often lending his voice to animated series and video games.