Films:
* The Help (2011) - Minny Jackson
* Insidious (2010) - Elise Rainier
* Hidden Figures (2016) - Dorothy Vaughan
* The Shape of Water (2017) - Zelda Fuller
* Ma (2019) - Sue Ann Ellington
* The Shack (2017) - Papa
* Instant Family (2018) - Octavia
* Blackbird (2021) - Lily
* Luce (2019) - Rosemary
* Smallfoot (2018) - Meechee (voice)
Television:
* Ugly Betty (2006-2010) - Constance Grady
* The Big C (2010-2013) - Patricia
* Selfie (2014) - Dr. Jodi
* Mom (2013-2021) - Barbara
* Truth Be Told (2019-present) - Poppy Parnell
* The Little Mermaid Live! (2019) - Ursula (live performance)
* Little Fires Everywhere (2020) - Mia Warren
* The Midnight Sky (2020) - Suzanne
This is just a sampling of her extensive work. She has also lent her voice to several animated films and has received numerous accolades for her performances, including an Academy Award, a Golden Globe Award, and two Screen Actors Guild Awards.