Movies:
* The Wrong Guys (1988): Piscopo plays a former baseball player who becomes embroiled in a kidnapping scheme.
* The Super Mario Bros. Super Show! (1989): Piscopo voiced the character of Luigi in this animated series.
* The Adventures of Ford Fairlane (1990): He plays a sleazy gossip columnist in this action comedy starring Andrew Dice Clay.
* The Pickle (1993): Piscopo appears as a nervous pizza delivery man in this quirky comedy.
* The Santa Clause (1994): He plays a toy store manager in this Christmas classic starring Tim Allen.
* The Wedding Singer (1998): Piscopo has a cameo appearance as a wedding DJ.
* My Big Fat Greek Wedding (2002): He plays a restaurant owner in this romantic comedy.
* The Italian Job (2003): He plays a character named "Big Tony" in this action-comedy.
* The Pursuit of Happyness (2006): He plays a stockbroker in this biographical drama starring Will Smith.
* The Godfather of Harlem (2019): Piscopo had a recurring role as the mobster “Frankie” in this drama series.
Television:
* Saturday Night Live (1980-1984): Piscopo was a cast member on the show, known for his impressions of celebrities like Frank Sinatra, Elvis Presley, and Ronald Reagan.
* The George Piscopo Show (1988-1989): He starred in his own sitcom for one season.
* The Piscopo Show (1989): He hosted a short-lived talk show.
* The George Piscopo Show (2001): He hosted another late-night talk show.
* The Sopranos (2004): He guest-starred in an episode of this acclaimed drama series.
* Law & Order: Special Victims Unit (2006): He appeared in an episode of this popular police procedural.
* Everybody Loves Raymond (2003-2005): Piscopo had a recurring role as the character "Frank" in this sitcom.
* The Bold and the Beautiful (2018-2019): He appeared as a recurring character in this soap opera.
This is just a sampling of George Piscopo's extensive work in film and television. He has also appeared in many other projects, including guest spots on various television shows and voice-over work. He remains a popular performer and comedian.