Movies:
* Nirmalyam (1973): His debut film, directed by the legendary Adoor Gopalakrishnan, which launched his career.
* Kodiyettam (1977): Another film by Adoor Gopalakrishnan, known for its artistic brilliance.
* Elippathayam (1981): A masterpiece by Adoor Gopalakrishnan, where Babu Nampoothiri delivered a remarkable performance.
* Mathilukal (1989): A critically acclaimed film by Adoor Gopalakrishnan, showcasing his acting prowess.
* Kathapurushan (1989): Directed by G. Aravindan, this movie featured a powerful performance by Babu Nampoothiri.
* Vidheyan (1993): A film by Adoor Gopalakrishnan that won numerous awards, including the National Film Award for Best Actor for Babu Nampoothiri.
* Yathra (1985): A film by Jayaraj that won the National Film Award for Best Feature Film.
* Agninakshatram (1988): A popular film directed by I. V. Sasi, showcasing his versatility.
* Ente Sooryaputhri (1986): A romantic drama directed by Priyadarshan.
* His Highness Abdullah (2007): A historical drama film.
* Chaappa Kurishu (2011): A critically acclaimed film, depicting the story of a priest.
Television:
* Maala (2006): A popular Malayalam television serial.
* Chandanamazha (2012): A long-running television serial.
* Manjil Virinja Poovu (2017): A popular Malayalam television serial.
This is not an exhaustive list, but it highlights some of his most notable works. Babu Nampoothiri has received numerous awards and accolades for his contributions to Indian cinema, including the National Film Award for Best Actor and the Padma Shri in 2008. He is known for his intense and realistic acting style and is considered one of the greatest actors in Malayalam cinema.