Television:
* Ally McBeal (1998-2002): This was her breakout role, playing the quirky and ambitious lawyer Nelle Porter. It earned her a Golden Globe nomination.
* Arrested Development (2003-2006, 2013, 2018-2019): De Rossi played the sophisticated and often sarcastic Lindsay Fünke, a role that became a fan favorite.
* Scandal (2012-2017): De Rossi played the ambitious and manipulative Elizabeth North, the White House Chief of Staff.
* The Ellen Show (2004-2022): While not an acting role, she was a regular presence on The Ellen Show, which she co-produced and was often seen interviewing guests and participating in segments.
* Now and Then (2022): She portrayed a character named Jessica in this Apple TV+ series.
Film:
* Scream 2 (1997): Her first major film role, playing a student named Murphy.
* The Night We Called It a Day (1998): A starring role in a romantic drama.
* The Girl Next Door (2004): She played a mysterious neighbor.
* Cursed (2005): A starring role in this horror film about a group of friends who find themselves cursed.
* Who Is Clark Rockefeller? (2010): A television movie where she played the titular character, a con artist.
* The Time Traveler's Wife (2009): A supporting role in this romantic film adaptation.
Other:
* The Ellen Show (2004-2022): She was a co-producer and frequently appeared on the show.
* The Portia de Rossi Podcast: She hosted this podcast about her life, experiences, and insights.
This list is not exhaustive, but highlights some of the most prominent and successful projects she has been involved in.