Film:
* The Crow: City of Angels (1996): Played the role of Sarah, a woman who seeks revenge after her husband's murder.
* The Last Days of Disco (1998): Played a small role as a party guest.
* The Wicker Man (2006): Played a cameo role as a barmaid.
* The Secret Lives of Dorks (2006): Provided the voice for the character of Mrs. Malkin.
* The Boat That Rocked (2009): Played the role of "The Duchess", a radio DJ.
* The Lighthouse (2019): Played the role of a woman seen in a hallucination.
Television:
* The X-Files (1998): Appeared in one episode, "Hollywood A.D.", as the character of "Mother".
* The Sopranos (2002): Appeared in one episode, "Toodle-Fucking-Oo", as the character of "Gloria".
* The Shield (2003): Appeared in one episode, "The Blue Knight", as the character of "The Woman".
* The L Word (2004): Appeared in one episode, "Luminous", as the character of "Alison".
* Gilmore Girls (2007): Appeared in one episode, "The Real McCoy", as the character of "Gypsy".
* Torchwood (2007): Appeared in one episode, "Meat", as the character of "Rita".
* Doctor Who (2010): Appeared in one episode, "The Eleventh Hour", as the character of "Adelaide Brooke".
* Terminator: The Sarah Connor Chronicles (2008-2009): Appeared in three episodes, as the character of "Catherine Weaver".
* The Good Wife (2010-2016): Appeared in one episode, "The Last Supper", as the character of "Renée Royce".
* House of Cards (2015): Appeared in one episode, "Chapter 45", as the character of "Rachel Posner".
* American Horror Story: Apocalypse (2018): Appeared in one episode, "Return to Murder House", as the character of "Ms. Meade".
* The Expanse (2015-2022): Appeared in multiple episodes, playing the recurring role of "Naomi Nagata".
Other projects:
* Manson has also provided voice-overs for several video games, including "Guitar Hero: World Tour" and "The Sims 3: Late Night".
This list is not exhaustive, as Manson has made other smaller appearances in various projects throughout her career.