Here's what we know:
* He wasn't known for it: While Holmes is brilliant at deduction and observation, he isn't typically portrayed as a master of disguise. He relies more on his intellect and keen eye than physical transformations.
* Occasional disguises: There are instances where Holmes adopts a disguise, but these are usually simple and temporary. For example, in "The Adventure of the Speckled Band," he dresses as a clergyman to gain access to a house.
* Limitations: Holmes does mention the difficulty of disguises, especially in "The Sign of Four," stating that "a man's face is his most distinguishing feature." This suggests that he doesn't believe in the effectiveness of complete disguise.
So, while he might have occasionally used disguises, Sherlock Holmes's main focus was on deduction, not physical transformation. His true mastery lay in his mind, not his makeup kit.