The game doesn't have Exodia the Forbidden One or any of its pieces as playable cards. Exodia is a popular character from the *Yu-Gi-Oh!* anime and manga, but it wasn't introduced into the official card game until the *Legend of Blue-Eyes White Dragon* set, which came out after *Reshef of Destruction*.
The game's focus is on the Egyptian God Cards (Slifer the Sky Dragon, Ra the Mighty, and Obelisk the Tormentor), which are the main antagonists in the *Reshef of Destruction* storyline.