Some of the key differences between the manga and anime include:
* The order of events is different. In the manga, some events happen earlier or later than they do in the anime. For example, in the manga, Teito Klein meets Frau in the first chapter, while in the anime, they don't meet until episode 8.
* Some characters are different. In the manga, there are some characters who do not appear in the anime, and some characters who appear in the anime do not appear in the manga. For example, the character of Ceres does not appear in the manga, while the character of Mikage does not appear in the anime.
* The ending is different. The manga and anime have different endings. In the manga, Teito Klein and Frau's journey concludes differently than it does in the anime.
Overall, the 07-Ghost manga and anime are two distinct and separate interpretations of the same story. While they share some similarities, there are also many differences between the two versions.